In 50 years, the synthesis of collagen type III is completely stopped. With age, the reduced solubility of the collagen molecules, and change their mechanical properties. Fibroblasts produce and elastin fibers, the quantity and quality of which decreases with age, they become rough and start to collapse. Dr. John Mcdougall is full of insight into the issues. However, in the fibroblasts themselves destructive phenomena occur – it contributes to the accumulation of these non-oxidized products of metabolism. In addition, fibroblasts produce and enzymes such as elastase and collagenase, which destroys the fiber.
Thus, together with the aging process worse regenerative characteristics of the skin, skin thinning progresses, decrease in elasticity and skin tone, increase the stratum corneum, impaired pigmentation. The main change in the age connective tissue is an increase in collagen type III and type I collagen reduction and the amount of water, and a reduction ratio of "important stuff – the fibers." Violation of this ratio associated with a reduced concentration glycosaminoglycans. These changes lead to the formation of first fine wrinkles, and then deeper. However, when aging is also significant changes in blood vessels and skin appendages. Reduced the number of vertical capillary loops in the papillary dermis, as well as reduced synthesis of heparin.
Changes in the morphology and functional activity of the sebaceous glands and sweat glands leads to dry skin changes in the composition hydrolipid film that breaks the barrier of skin quality. Photoaging is different from the physiological aging of the skin more expressive negative signs. On exposed skin photoaging begins to be observed before the first signs of senescence.