Acetil Coenzima

From this it saw, to the end of 10 necessary enzymatic reactions if it gets the piruvato molecule, a precursor of the molecule of Acetil Coenzima (acetil CoA) that it is the first molecule that of the origin to the acid cycle of the citric one or cycle of Krebs. The glicoltica way has a great impact in the process of degradation of the glucose molecule for supplying the necessary precursor for the oxidativos steps (ALBERTS et al., 2006). The first enzyme of the glicoltica way is hexoquinase, that it promotes to the fosforilao of the glucose molecule with expense of a ATP to glucose 6 fosfato (G6P) hindering its exit cellular it citosol, and thus promoting the continuity of the glicoltica way. After its action, the enzyme fosfoglicoisomerase, isomeriza the G6P in frutose 6 P (F6P) preparing the molecule for the third and main step of the glicoltica way (MARCONDES, 2009). The third step is regulated by the enzyme fosfofrutoquinase (PFK), that it promotes the fosforilao of the F6P in carbon 1 (C1), transforming into frutose 1, 6 Bifosfato (F1,6BP) as shows figure 1, this step is irreversible and also it possesss expense of a ATP. This reaction needs the co-factor Magnesium, so that the reaction occurs and great rapidity successfully. In this stage we have the main moment of metabolic control of the glicoltica way, had the presence of fosfofrutoquinase (GRECHI, 2010; MARCONDES, 2009). 3,2 Frutose frutose is a monossacardeo and as well as the glucose, energy source and the main molecule for attainment of piruvato after being divided in two trioses for the enzyme aldolase B in the glicoltica way. It can in such a way be proceeding from the isomerizao of the glucose molecule, as of the alimentary diet of the fruits, you sweeten and of the hortalias, and even though of the metabolism of sorbitol (MIRES et al., 2005).

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